the choice of a suitable cellular model system is important

From each one of these observations it is sug gested that curcumin may be employed alone or can be com bined with classical anti-tumor drugs so as to sustain the immune capacity of the host, which can be affected by the disease or the treatment or may be the both. Curcumin a numerous edged blade Above discussions about the broad biological Celecoxib activity of the phytochemical demonstrate our hypothesis that curcumin asserts its anti tumor activity in cancer cells by altering the deregulated cell cycle via cyclin dependent, p53 dependent and p53 independent pathways. Such influences of curcumin upon key signal transduction pathways of cell cycle and performance in animal model systems have qualified it as a multiple edged sword in net bating the lethal disease cancer. Considering the fact that disruption of cell-cycle plays an important role in cancer progression, its modulation by curcumin seems to be a sensible approach in carcinogenesis. All the plant products with some of them powerful antioxidants and anti-cancer activity act are powerful modulators Infectious causes of cancer of protein kinases phosphatases that are associated with cell cycle regula tion. Several phyto-chemicals are sometimes area of the human diet or consumed as dietary supplement, and don't show adverse health effects even at-large doses. Due to failure of conventional chemotherapy beforehand levels of cancer and its huge undesireable effects, cancer chemopre vention by this phytochemical in a definite molecular tar get method may play a crucial part in future in reducing cancer incidence in addition to the amount of deaths caused by this disease. Prospects for the near future Previous seminal work, described above has demon strated curcumin inhibition of important PR-619 molecular mechanisms of tumorigenesis. Results have already been shown of typical signaling intermediates that influence the growth pheno type. Major developments in the comprehension of cell cycle regulation components provided an improved familiarity with the molecular interactions involved with human cancer. Moreover, the components of the cell-cycle are probably associated with other non cancerous conditions and their position must be defined. Further mechanistic work nevertheless, is required to examine curcumin results on common effector pathways that are connected by switches that regulate cell behavior, cell death and phenotype modification or lineage determination. Human treatment reports of curcumin, whether alone or in combination, are indicated against intermediate biomarkers and morphological stages of fuel trointestinal tumorigenesis. Curcumin might ergo provide a useful part of dietary or medicinal handle ment targeted at reduction of the occurrence of and mortality from cancer. The autonomic nervous system through its hypothalamic neuroendocrine get a handle on of puberty, menarche and skele tal growth contributes importantly to the pathogen esis of AIS. Melatonin and its signaling pathway dysfunction and platelet calmodulin dysfunction found in AIS topics include the autonomic nervous system.